Pathophysiology & Pharmacology Game
Build Disease Mechanisms.Block Them With Drugs.
Not by memorizing facts — by tracing the mechanism from trigger to clinical outcome, then blocking the pathway with the right drug. 550 puzzles across 10 body systems.
Google Play soonCan you connect the chain?
Every link matters. Miss one, and the pathway breaks.
Now can you treat it?
A disease pathway is active. Five drugs sit in your cart. Only one hits the right molecular target.
Choose wrong, and the cascade continues.
Game Modes
Five ways to master mechanisms
Mechanism Chains
FREE · 200 chainsDrag and connect steps from trigger to clinical outcome. Understand why each step causes the next.
Reverse Mode
PREMIUMStart with a clinical finding and trace backwards to the root cause.
Versus Mode
PREMIUMTwo similar diseases side by side. Fill in the gaps to learn what makes them different.
Daily Challenge
DAILYOne new chain every day. Build your streak in under 3 minutes.
Treat Mode
A disease pathway is active. Drag the correct drug onto the right molecular target to block the cascade. Learn pharmacology by mechanism, not memorization.
Five drugs in your cart. Only one hits the right target. Choose wrong, and the cascade continues.
Content
10 Body Systems
Pathophysiology chains AND pharmacology puzzles in every system.
Cardiovascular
Heart failure, ACS, shock, arrhythmias, hypertension
Respiratory
COPD, asthma, pulmonary embolism, ARDS, cystic fibrosis
Renal
AKI, CKD, nephrotic vs nephritic, electrolyte disorders
GI & Hepatology
Cirrhosis, peptic ulcer, GI bleeding, hepatitis C
Neurology
Stroke, seizures, Parkinson's, depression, myasthenia gravis
Endocrine
DKA, thyroid storm, adrenal insufficiency, acromegaly
Infectious Disease
TB, HIV, MRSA, fungal meningitis, PCP
Hematology
Anemias, HIT, CML, hemophilia, sickle cell disease
Reproductive
Preeclampsia, PCOS, breast cancer, PPH
Rheumatology
Gout, RA, SLE, vasculitis, MAS
Every completed chain ends with a clinical pearl referenced to Robbins & Cotran, Harrison's, Guyton & Hall, Goodman & Gilman's, and Pathoma.
Who is PathoPlay for?
Medical Students
Preparing for USMLE and pathophysiology exams
Nursing Students
Mastering disease mechanisms for NCLEX
PA, NP & Pharmacy Students
Building clinical reasoning foundations
Anyone curious
Who wants to understand why diseases happen and how drugs work
Why PathoPlay Works
Most study tools ask you to recall facts.
PathoPlay asks you to think.
By building mechanism chains and blocking them with the right drug, you develop deep understanding that survives exam pressure and translates to real clinical reasoning.
Simple Access. No Complications.
Free
- 200 pathophysiology chains
- All 10 body systems
- No ads
- Fully offline
All Access
One-time purchase · no subscriptions
- All 550 puzzles
- Reverse + Versus + Treat modes
- Daily Challenge
- All future content
From the makers of MedDiagnosis — the clinical case simulator trusted by medical students worldwide.
PathoPlay builds the foundation. MedDiagnosis puts it into practice.
Explore MedDiagnosis FAQ
Frequently Asked Questions
Yes. 200 Forward chains are completely free across all 10 body systems. No time limits, no ads, no strings attached.
Reverse, Versus, Treat modes, Daily Challenge, and all future content updates. One-time purchase — no subscriptions.
You're not memorizing — you're building the pathway step by step and learning where drugs intervene. Active construction beats passive recall.
Yes. Treat mode teaches pharmacology by mechanism. You learn WHERE each drug works in the disease pathway, not just what it does.
Robbins & Cotran Pathologic Basis of Disease, Harrison's Principles of Internal Medicine, Guyton & Hall Textbook of Medical Physiology, Goodman & Gilman's The Pharmacological Basis of Therapeutics, Pathoma, and current clinical guidelines.
Yes, fully offline. No internet required once downloaded.
Coming soon to Google Play. Available now on the App Store.
Ready to build
disease mechanisms?
Free to start. No credit card required.
Google Play coming soonEducational use only. Not for clinical decision-making. Evidence-based content referenced to Robbins & Cotran, Harrison's, Guyton & Hall, Goodman & Gilman's, and Pathoma. USMLE® is a trademark of NBME/FSMB. No affiliation or endorsement.